Meta-analysis for a single mean estimate

*Blog post
2010
Systematic overview
Author

Steve Simon

Published

February 11, 2010

Someone noted that the usual meta analysis is carried out for the study on two treatment groups, usually for a difference in means. What if you had several studies estimating not a difference in means, but just estimates of a single mean. Could you conduct a meta-analysis in this situation?

Yes, you can do this. The statistics change slightly, but in a predictable and logical way. The general concept and the general procedures stay the same.

It gets a bit trickier when the statistic of interest is a single proportion (e.g., sensitivity/specificity), especially when there are some publications where the proportion equals 1.0. If you try to weight by the inverse variance, these studies get infinite weight.

Earlier versions are here and here.