Another top ten study in EBM (February 14, 2005)

Here's another nomination for the top ten studies in EBM.

One of the pitfalls of research evaluating diagnostic tests is spectrum bias, and this was noted as early as 1978 in

This is a good article to cite, because one of the authors, AR Feinstein, was pivotal in the development of Clinical Epidemiology, which he defined as

the clinicostatistical study of diseased populations. The intellectual activities of this territory include the following: the occurrence rates and geographic distribution of disease; the patterns of natural and post-therapeutic events that constitute varying clinical courses in the diverse spectrum of disease; and the clinical appraisal of therapy. -- as quoted in

I have a brief weblog entry about spectrum bias:

This page was written by Steve Simon while working at Children's Mercy Hospital. Although I do not hold the copyright for this material, I am reproducing it here as a service, as it is no longer available on the Children's Mercy Hospital website. Need more information? I have a page with general help resources. You can also browse for pages similar to this one at Category: Teaching resources.